Hesperidin, a bioflavonoid found in citrus fruits, has shown significant potential in promoting health due to its diverse pharmacological properties, including antioxidant, anti-inflammatory, and cardiovascular benefits.
Pharmacological Properties
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Antioxidant Activity
Hesperidin effectively neutralizes free radicals, reducing oxidative stress linked to chronic diseases like cardiovascular disease and cancer. -
Anti-inflammatory Effects
It inhibits pro-inflammatory cytokines and enzymes, beneficial in conditions such as arthritis and inflammatory bowel disease. -
Cardiovascular Benefits
Hesperidin enhances endothelial function, lowers blood pressure, and prevents platelet aggregation, reducing hypertension and atherosclerosis risk. -
Metabolic Health
It improves lipid profiles and glucose metabolism, beneficial for managing metabolic syndrome and type 2 diabetes. -
Neuroprotective Effects
Hesperidin’s properties mitigate neuronal damage, offering potential benefits for neurodegenerative diseases.
Clinical Evidence and Applications
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Supplementation and Dosage
Available as a dietary supplement, typical dosages range from 500 to 1000 mg daily, with formulations enhancing absorption. -
Safety and Side Effects
Generally safe, hesperidin may cause mild gastrointestinal symptoms in some individuals.
Hesperidin is a promising natural compound for reducing oxidative stress, inflammation, and supporting cardiovascular and metabolic health. While further clinical trials are needed, its inclusion in a balanced diet can contribute to overall health and disease prevention.
Find it in the Vit&Min + CoQ10 supplement here!!!
References
- Hesperidin inhibits lung fibroblast senescence via IL-6/STAT3 signaling pathway to suppress pulmonary fibrosis
- Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence
- Hesperidin Anti-Osteoporosis by Regulating Estrogen Signaling Pathways
- Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression
- Hesperidin, a Bioflavonoid in Cancer Therapy: A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways
- The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect
- Hesperidin from Orange Peel as a Promising Skincare Bioactive: An Overview
