Hesperidin, a bioflavonoid found in citrus fruits, has shown significant potential in promoting health due to its diverse pharmacological properties, including antioxidant, anti-inflammatory, and cardiovascular benefits.
Pharmacological Properties
1. Antioxidant Activity
Hesperidin effectively neutralizes free radicals, reducing oxidative stress linked to chronic diseases like cardiovascular disease and cancer.
2. Anti-inflammatory Effects
It inhibits pro-inflammatory cytokines and enzymes, beneficial in conditions such as arthritis and inflammatory bowel disease.
3. Cardiovascular Benefits
Hesperidin enhances endothelial function, lowers blood pressure, and prevents platelet aggregation, reducing hypertension and atherosclerosis risk.
4. Metabolic Health
It improves lipid profiles and glucose metabolism, beneficial for managing metabolic syndrome and type 2 diabetes.
5. Neuroprotective Effects
Hesperidin’s properties mitigate neuronal damage, offering potential benefits for neurodegenerative diseases.
Clinical Evidence and Applications
1. Supplementation and Dosage
Available as a dietary supplement, typical dosages range from 500 to 1000 mg daily, with formulations enhancing absorption.
2. Safety and Side Effects
Generally safe, hesperidin may cause mild gastrointestinal symptoms in some individuals.
Hesperidin is a promising natural compound for reducing oxidative stress, inflammation, and supporting cardiovascular and metabolic health. While further clinical trials are needed, its inclusion in a balanced diet can contribute to overall health and disease prevention.
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